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Sertoli Cell Function in Young Males with Metabolic Syndrome
Uma Kaimal Saikia1, Kunjan Saikia1, Dipti Sarma1
1Department of Endocrinology, Gauhati Medical College, Guwahati, Assam, India.
Indian Journal of Endocrinology and Metabolism
|June 5, 2019
Summary
Metabolic syndrome (MetS) is linked to hypogonadism and impaired testicular function in young men. This study found MetS significantly lowers testosterone, FSH, and inhibin B, impacting sperm count and motility.
Area of Science:
- Endocrinology
- Reproductive Medicine
- Metabolic Disorders
Background:
- Metabolic syndrome (MetS) prevalence is rising globally, including India.
- Beyond cardiovascular risks, MetS is increasingly associated with testicular dysfunction and male infertility.
Purpose of the Study:
- To evaluate hypogonadism and Sertoli cell dysfunction in young adult males with MetS.
- To correlate these reproductive parameters with MetS components.
Main Methods:
- A cross-sectional study involving 50 young adult males (20-40 years) with MetS and 30 age-matched controls.
- Clinical examination and fasting laboratory tests including glucose, lipids, FSH, inhibin B, and total testosterone (Te).
- Semen analysis was performed after 3 days of abstinence.
Main Results:
- MetS subjects exhibited significantly lower total Te, FSH, and inhibin B levels.
- Reduced semen volume, sperm count, and motility (total and progressive) were observed in MetS patients.
- Waist circumference negatively correlated with sperm count, while triglycerides negatively associated with semen volume.
Conclusions:
- Metabolic syndrome induces hypogonadotropic hypogonadism, evidenced by low Te, FSH, and inhibin B.
- Semen abnormalities in MetS patients indicate underlying Sertoli cell dysfunction.
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