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Related Concept Videos

Schizophrenia01:17

Schizophrenia

838
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
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Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

5.8K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
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Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

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Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
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Related Experiment Video

Updated: Jan 23, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
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Migration and schizophrenia: meta-analysis and explanatory framework.

Jonathan Henssler1, Lasse Brandt1, Martin Müller2,3

  • 1Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

European Archives of Psychiatry and Clinical Neuroscience
|June 5, 2019
PubMed
Summary
This summary is machine-generated.

First- and second-generation migrants have a higher risk of developing non-affective psychotic disorders. Social exclusion and discrimination are key factors contributing to these increased rates.

Keywords:
Bayesian inferenceDopamineMeta-analysisMigrationPsychosisStress

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Area of Science:

  • Psychiatry
  • Epidemiology
  • Neuroscience

Background:

  • Previous research indicates elevated rates of schizophrenia and related psychoses in migrant populations.
  • Non-affective psychotic disorders represent a significant public health concern within migrant communities.

Purpose of the Study:

  • To conduct a meta-analysis on the incidence of non-affective psychotic disorders in first- and second-generation migrants.
  • To explore the relationship between migration, social stress, and the development of psychotic experiences.

Main Methods:

  • Systematic review and meta-analysis of studies on non-affective psychotic disorders in migrants.
  • Examination of effect estimates for incidence risk among migrant groups compared to native populations.

Main Results:

  • Substantial evidence indicates an increased relative risk of incidence for non-affective psychotic disorders among first- and second-generation migrants.
  • High heterogeneity across studies necessitates cautious interpretation of effect estimates.

Conclusions:

  • Social exclusion and discrimination are proposed as central factors in the elevated rates of psychotic experiences among individuals with a migration background.
  • A framework linking cultural communication differences and discrimination to neurobiological correlates of psychosis is presented.