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Updated: Jan 23, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
The Genetic Association of IFN-λs with Human Inflammatory Disorders Remains a Conundrum
Sreedhar Chinnaswamy1, Marek L Kowalski2,3
1National Institute of Biomedical Genomics, Kalyani, West Bengal, India.
Abstract:
Type III Interferons (IFNs) or lambda IFNs (IFN-λs or IFNLs) although are primarily antiviral cytokines, may have roles to play in shaping immune responses, including those during inflammation. Genetic variants within the IFNL locus have been shown to be associated with various inflammatory conditions in humans ranging from metabolic to autoimmune and allergic diseases. The mechanism behind these genetic associations is not clear. Appropriate data analysis methods and functional evidence should be complimentarily used to identify the causal variants and mechanisms.
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