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Cell-mediated immunity in vitro in atopic dermatitis.

M Horsmanheimo, A Horsmanheimo, C H Banov

    Archives of Dermatology
    |February 1, 1979
    PubMed
    Summary

    T cell function in atopic dermatitis is impaired, with reduced release of leukocyte migration inhibition factor (LIF) and decreased lymphocyte response to PPD in patients compared to controls.

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    Clinical therapeutics·1996

    Area of Science:

    • Immunology
    • Dermatology
    • Cellular Biology

    Background:

    • Atopic dermatitis (AD) is a chronic inflammatory skin disease.
    • T cell dysfunction is implicated in the pathogenesis of AD.

    Purpose of the Study:

    • To investigate T cell function in patients with atopic dermatitis.
    • To compare T cell responses in AD patients versus healthy individuals.

    Main Methods:

    • Leukocyte migration agarose assay.
    • Lymphocyte transformation tests.
    • Assessed phytohemagglutinin (PHA)- and PPD-induced responses.

    Main Results:

    • Significantly decreased phytohemagglutinin (PHA)- and PPD-induced leukocyte migration inhibition factor (LIF) release from lymphocytes in AD patients (P < .001).
    • Reduced blastogenic response of lymphocytes to PPD in AD patients compared to controls (P < .01).
    • No significant differences in spontaneous blastogenesis or responses to PHA, concanavalin A (ConA), or streptokinase-streptodornase (SK-SD).

    Conclusions:

    • T cell function, specifically LIF production and PPD response, is demonstrably impaired in atopic dermatitis.
    • These findings suggest a role for altered T cell-mediated immunity in the pathophysiology of AD.

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