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Pediatric Adenocarcinoma in Korea: A Multicenter Study
Hee-Beom Yang1, Jung-Man Namgoong2, Ki Hoon Kim3
1Department of Pediatric Surgery, Seoul National University Children's Hospital, Seoul, Korea.
Cancer Research and Treatment
|June 6, 2019
Summary
Pediatric adenocarcinoma is rare but occurs in various organs, often diagnosed at advanced stages. Survival rates vary by cancer site and carcinoembryonic antigen levels, necessitating further research.
Area of Science:
- Pediatric Oncology
- Cancer Research
- Epidemiology
Background:
- Adenocarcinoma is a rare malignancy in children.
- Research on pediatric adenocarcinoma in Korea is limited.
- Understanding clinical features is crucial for this rare population.
Purpose of the Study:
- To investigate the clinical features of pediatric adenocarcinomas across various primary organ sites in Korea.
- To analyze patient and tumor characteristics.
- To estimate survival rates for pediatric adenocarcinoma.
Main Methods:
- Retrospective review of pediatric patients (<18 years) diagnosed with adenocarcinoma between 1995 and 2016.
- Analysis of patient demographics, tumor location, and stage.
- Calculation of 5-year overall survival rates and confidence intervals.
Main Results:
- Eighty patients were analyzed, with common sites including colon/rectum, ovaries, and stomach.
- Over half of the patients (54.8%) were diagnosed at advanced stages (3 or 4).
- Five-year survival rates varied significantly by cancer site (e.g., non-GI 78.8% vs. GI 44.7%) and carcinoembryonic antigen levels.
Conclusions:
- Pediatric adenocarcinomas present across diverse organs and are frequently diagnosed at advanced stages.
- Significant differences in survival rates were observed based on tumor origin and biomarker levels.
- Further large-scale, prospective studies are essential to define accurate clinical characteristics and prognostic factors.
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