Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Emerging Adulthood01:27

Emerging Adulthood

648
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
648
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

14.8K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
14.8K
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

306
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
306
Fixed Action Patterns01:06

Fixed Action Patterns

17.6K
A fixed action pattern (FAP) is a specific, hard-wired sequence of behaviors that occurs in response to an external stimulus, called a sign stimulus. The behavior is “fixed” because it is essentially unchangeable—proceeding similarly across individuals of a species every time it occurs.
17.6K
Applications of GIS: Disaster Management and Emergency Response01:29

Applications of GIS: Disaster Management and Emergency Response

488
Geographic Information System (GIS) technology is essential for risk identification, action prioritization, and resource optimization in critical situations like flooding and earthquakes. By integrating spatial and demographic data, GIS provides a comprehensive framework for emergency response.GIS integrates data layers, like rainfall intensity, topography, elevation profiles, and river levels, to model high-risk flood zones. These layers assess areas susceptible to flooding based on their...
488
Patterns of Fever01:26

Patterns of Fever

3.8K
Before understanding the types and patterns of fever, it is essential to know its phases.
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-platform reassessment of human mitochondrial DNA methylation reveals signals consistent with technical artifacts.

bioRxiv : the preprint server for biology·2026
Same author

Spatially segregated B- and T-lymphoblasts in mixed-phenotype acute leukemia with BCR::ABL1.

Journal of hematopathology·2026
Same author

Association Between Clonal Hematopoiesis and Cardiometabolic Disease: A Systematic Review and Meta-Analysis.

JACC. CardioOncology·2026
Same author

A Novel PDZRN3::BRAF Fusion as Potential Driver Mechanism in BAP1-inactivated Melanocytoma.

The American Journal of dermatopathology·2026
Same author

The adverse prognostic impact of HMGCLL1 gene variants can be abrogated by frontline second-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.

Leukemia·2026
Same author

Blood-based epigenetic instability linked to human aging and disease.

Nature communications·2026

Related Experiment Video

Updated: Jan 23, 2026

A Precise and Autonomous System for the Detection of Insect Emergence Patterns
06:22

A Precise and Autonomous System for the Detection of Insect Emergence Patterns

Published on: January 9, 2019

6.2K

Emerging patterns in clonal haematopoiesis.

Jose-Mario Capo-Chichi1, Phillip Michaels2, Rosemarie Tremblay-Le May2

  • 1Department of Molecular Genetics, Toronto General Hospital, Toronto, Ontario, Canada.

Journal of Clinical Pathology
|June 6, 2019
PubMed
Summary

Clonal hematopoiesis (CH) involves mutations in blood cells, increasing cancer and cardiovascular risks. This review details CH with gene mutations, focusing on detection technologies and nomenclature.

Keywords:
haematopathologyleukocytesmolecular genetics

More Related Videos

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

27.3K
Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.8K

Related Experiment Videos

Last Updated: Jan 23, 2026

A Precise and Autonomous System for the Detection of Insect Emergence Patterns
06:22

A Precise and Autonomous System for the Detection of Insect Emergence Patterns

Published on: January 9, 2019

6.2K
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

27.3K
Characterizing Mutational Load and Clonal Composition of Human Blood
07:58

Characterizing Mutational Load and Clonal Composition of Human Blood

Published on: July 11, 2019

7.8K

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Clonal hematopoiesis (CH) is characterized by acquired mutations in hematopoietic cells, predating malignancy.
  • CH is common in the elderly, linked to increased risks of hematological cancers like AML and cardiovascular events.
  • Small mutant clones are also found in AML remission, aplastic anemia, and pre-chemotherapy cancer patients, with varying implications.

Purpose of the Study:

  • To review clonal hematopoiesis specifically involving gene mutations detected by sequencing.
  • To discuss nomenclature and molecular technologies for detecting and quantifying these mutations.
  • To explore the clinical implications and genetic profiles associated with CH in different contexts.

Main Methods:

  • Review of existing literature on clonal hematopoiesis and gene mutations.
  • Focus on sequencing technologies for mutation detection and quantification.
  • Analysis of nomenclature and classification systems for CH.

Main Results:

  • CH with gene mutations is a distinct subset with significant clinical implications.
  • Factors like mutation type, clone size, age, and immune status influence disease biology.
  • Diverse genetic profiles are observed depending on the clinical context.

Conclusions:

  • Understanding CH with gene mutations is crucial for risk stratification and management.
  • Advances in molecular technologies are enhancing the detection and characterization of CH.
  • Further research is needed to elucidate the full spectrum of CH and its impact on health outcomes.