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Published on: March 26, 2018
Spatially segregated B- and T-lymphoblasts in mixed-phenotype acute leukemia with BCR::ABL1
Ingrid S Tam1,2, José-Mario Capo-Chichi1,2, Adam C Smith1,3
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Background:
Mixed phenotype acute leukemias (MPALs) account for approximately 2-5% of acute leukemias.
Purpose:
We report a case of MPAL with BCR::ABL1 demonstrating striking spatial segregation of B- and T-lymphoblasts involving the bone marrow and cervical lymph node, respectively.
Methods:
Morphologic, immunophenotypic, and genetic characterization were performed.
Results:
These studies identified two distinct lineage-specific blast populations. Molecular studies demonstrated shared genetic features, supporting a common clonal origin.
Conclusions:
This case expands the clinicopathologic spectrum of MPALs and raises the possibility of lineage-restricted differentiation occurring in distinct tissue microenvironments.
