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Related Concept Videos

Schizophrenia01:17

Schizophrenia

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Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
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Biological Causes of Schizophrenia01:29

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
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Psychological and Sociocultural Causes of Schizophrenia01:29

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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

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Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
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Accelerators

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Accelerators in concrete serve as admixtures to speed up the hardening process, enabling the concrete to achieve early strength faster. Although accelerators do not necessarily impact the time it takes concrete to set, they reduce this time in practice. A common accelerator is calcium chloride, which is particularly useful for hastening early strength development in cold weather or for rapid repair jobs that require quick heat generation after mixing.
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VSEPR Theory for Determination of Electron Pair Geometries
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Related Experiment Video

Updated: Jan 23, 2026

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Methylation age acceleration does not predict mortality in schizophrenia.

Kaarina Kowalec1,2, Eilis Hannon3, Georgina Mansell3

  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. kaarina.kowalec@ki.se.

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Methylation age acceleration did not significantly predict mortality in schizophrenia (SCZ) patients overall. However, in sensitivity analyses excluding cancer cases, it was linked to increased mortality risk in SCZ.

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Area of Science:

  • Epigenetics
  • Psychiatry
  • Mortality Research

Background:

  • Schizophrenia (SCZ) is linked to elevated mortality rates.
  • DNA methylation patterns can estimate biological age (mAge), and deviations (mAge acceleration) correlate with mortality.
  • Investigating mAge acceleration in SCZ could reveal novel mortality predictors.

Purpose of the Study:

  • To examine the association between mAge acceleration and mortality in individuals with SCZ compared to controls.
  • To determine if mAge acceleration can predict mortality risk in the SCZ population.

Main Methods:

  • 190 SCZ cases and 190 controls from the Sweden Schizophrenia Study were analyzed.
  • DNA methylation was assessed using the Illumina MethylationEPIC array.
  • Cox proportional hazards regression modeled the link between mAge acceleration and mortality.

Main Results:

  • Primary analyses showed no significant association between mAge acceleration and SCZ mortality.
  • Sensitivity analyses excluding SCZ cases with prior cancer revealed a significant link between Hannum mAge acceleration and mortality (HR=1.13, p=0.005).

Conclusions:

  • The study did not confirm the primary hypothesis that mAge acceleration predicts mortality in SCZ.
  • A potential association may exist in specific SCZ subsets or for smaller effect sizes, warranting further investigation.