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SO2F2-mediated transformation of 2'-hydroxyacetophenones to benzo-oxetes
Revathi Lekkala1, Ravindar Lekkala1, Balakrishna Moku1
1State Key Laboratory of Silicate Materials for Architectures; School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China.
Beilstein Journal of Organic Chemistry
|June 6, 2019
Abstract:
A catalyst-free novel and efficient methodology for the challenging synthesis of benzo-oxetes from 2'-hydroxyacetophenones mediated by sulfuryl fluoride (SO2F2) gas has been realized. The combination of 2'-hydroxyacetophenones and SO2F2 furnishes synthetically challenging benzo-oxetanes in moderate to excellent yields. The highlight of this work is the design and synthesis of strained four-membered oxete rings.