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WashU Epigenome Browser update 2019.

Daofeng Li1,2, Silas Hsu1,2, Deepak Purushotham1,2

  • 1Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

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|June 6, 2019
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Summary
This summary is machine-generated.

The WashU Epigenome Browser offers enhanced epigenomic data visualization and analysis tools. New features include virtual reality integration and collaborative browsing for the scientific community.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • The WashU Epigenome Browser has been a key resource for epigenomic data visualization and analysis since 2010.
  • It has historically provided access to data from major consortia like ENCODE and Roadmap Epigenomics.

Purpose of the Study:

  • To present a refactored codebase and redesigned user interface for the WashU Epigenome Browser.
  • To introduce novel features enhancing data visualization, integration, and collaborative analysis of epigenomic datasets.

Main Methods:

  • Refactoring of the existing codebase.
  • Redesign of the user interface.
  • Development and implementation of new features including VR visualization, expanded data hubs, improved UI responsiveness, interaction history, and live collaborative browsing.

Main Results:

  • A significantly improved and more responsive user interface.
  • Introduction of virtual reality (VR) visualization capabilities for 3D chromatin structure and education.
  • Expansion of public data hubs to include multiple large-scale consortia (4DN, ENCODE, Roadmap, TaRGET, IHEC, TCGA).
  • Implementation of collaborative features like Live Browsing and interaction history (undo/redo).
  • Support for visualizing local tracks and data hubs.

Conclusions:

  • The redesigned WashU Epigenome Browser offers advanced tools for exploring complex epigenomic data.
  • New features facilitate enhanced biological discovery, education, and remote collaboration.
  • The platform continues to serve as a vital resource for the epigenomics research community.