Related Experiment Video
Updated: Jan 23, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
An unexpected cause of dysphagia: pleural mesothelioma
Sagrario María Santos Seoane1, Raquel Yano Escudero2, Víctor Arenas García3
1Medicina Interna, Hospital de Cabueñes, España.
Abstract:
Malignant mesothelioma usually originates from the pleura or peritoneum, and has a poor prognosis. The incidence of this type of tumor is increasing worldwide, which is probably a result of occupational or environmental exposure to asbestos. In 90% dyspnea, chest pain or a combination of both are usually the initial symptoms. Dysphagia only occurs in 1.4% and is very rare as the initial symptom. We present the case of a middle-aged patient, in whom the initial symptom was dysphagia, so an endoscopy was performed. This showed extrinsic compression of the esophagus that was demonstrated when performing the chest X-ray, in which it was revealed a posterior mediastinal mass surrounding the esophagus concentrically without mucosal invasion.
Insights
Malignant mesothelioma, a rare cancer, can present with unusual initial symptoms like dysphagia. This case highlights a posterior mediastinal mass causing esophageal compression as an early indicator.
Area of Science:
- Oncology
- Thoracic Surgery
Background:
- Malignant mesothelioma, often linked to asbestos exposure, typically affects the pleura or peritoneum.
- This cancer has a poor prognosis and increasing global incidence.
Observation:
- A middle-aged patient presented with dysphagia, an uncommon initial symptom for malignant mesothelioma.
- Endoscopy revealed extrinsic esophageal compression, prompting further investigation.
Findings:
- Chest X-ray identified a posterior mediastinal mass.
- The mass concentrically surrounded the esophagus without evidence of mucosal invasion.
Implications:
- This case underscores the importance of considering rare presentations of malignant mesothelioma.
- Early diagnosis through investigation of atypical symptoms like dysphagia is crucial for patient outcomes.
Related Concept Videos
Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
Pleural Disorders: Types and Brief Description
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:

