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Updated: Jan 23, 2026

Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
CLINICAL FEATURES OF PATCHY CHORIORETINAL ATROPHY IN PATHOLOGIC MYOPIA
Ran Du1, Yuxin Fang1, Jost B Jonas2
1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan; and.
Patchy atrophy in pathologic myopia affects the retina and Bruch membrane. Swept-source optical coherence tomography revealed defects in these layers, offering insights into myopia
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Pathologic myopia is a leading cause of vision impairment.
- Patchy atrophy (PA) is a significant finding in pathologic myopia.
- Understanding PA's morphology is crucial for myopia research.
Purpose of the Study:
- To detail the clinical characteristics of patchy atrophy in pathologic myopia.
- To evaluate the condition of the Bruch membrane and retinal pigment epithelium in PAs using swept-source optical coherence tomography (SS-OCT).
Main Methods:
- Retrospective review of highly myopic patients from January 2015 to February 2018.
- Identification of PAs using wide-field fundus photography and autofluorescence.
- Assessment of retinochoroidal status in PAs with SS-OCT.
Main Results:
- 456 PAs were identified in 137 eyes (118 patients), predominantly in the macular region.
- SS-OCT revealed retinal pigment epithelium defects in all scanned PAs (100%).
- Bruch membrane defects were observed in 82.9% of PAs, often smaller than RPE defects; scleral bulging noted in 10 PAs.
Conclusions:
- Morphological findings in PAs suggest potential biomechanical factors in their development.
- These insights contribute to understanding the pathogenesis of pathologic myopia.
- SS-OCT is valuable for characterizing PA and associated retinochoroidal changes.
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