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Kainic acid induced damage to the striatum increases DT diaphorase activity
M R Cohen1, N Sridhara, C N Ramchand
1Ensor Foundation Research Laboratory, William S. Hall Psychiatric Institute, Columbia, S.C.
Research Communications in Chemical Pathology and Pharmacology
|August 1, 1987
Abstract:
A significant increase in the striatal specific activity of DT diaphorase is demonstrable from one to six weeks after intrastriatal injection of kainic acid (KA). At six weeks, there is a significant dose-response relation (ANOVA, F(2,18) = 25.8, p less than 0.001); 1, 3 and 5 nmoles produce 12.3, 39.6 and 118% increases, respectively. Loss of acetylcholinesterase activity (AChE), used as an indicator of neuronal damage, is positively correlated with the enhanced DT diaphorase activity (r = 0.823, p less than 0.01).