Related Experiment Video
Updated: Jan 23, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
A randomized clinical trial of cavity liners after selective caries removal: one-year follow-up
Tássia Carina Stafuzza1, Luciana Lourenço Ribeiro Vitor1, Daniela Rios1
1Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Odontopediatria, Ortodontia e Saúde Coletiva, Bauru, São Paulo, Brasil.
Introduction:
Alternatives for the treatment of caries disease, such as minimally invasive approaches, have been developed in recent years.
Objective:
To carry out clinical and radiographic evaluations of three cavity liners after selective caries removal.
Methodology:
Thirty-six primary molars with deep occlusal caries lesions without pulp involvement (from children of both genders, aged between 5 and 8 years) were randomly divided into the following groups: calcium hydroxide cement (CHC) group; mineral trioxide aggregate (MTA) group and Portland cement with added zirconium oxide (PCZ) group. The following-up period was 6- and 12-month. The clinical and radiographic success rates were evaluated through chi-square test. The radiographic measurements were compared by ANOVA followed by Tukey's test (p<0.05).
Results:
Thirty-six patients were included, but thirty-four returned for 12-month follow-up. The overall success rate of the therapy for the three groups was 94.11% and no statistically significant differences occurred in the comparison among groups (p>0.05). Nineteen radiographs were selected to measure the dentin barrier thickness. The intragroup comparison presented a statistically significant increase of the dentin barrier for all groups, at 12-month follow-up. However, the MTA group showed increase of the dentin barrier, over time, 6- to 12-month follow-up. The intergroup comparison revealed no statistically significant differences (p>0.05).
Conclusion:
The clinical and radiographic data showed that all cavity liners provided effective treatment of primary teeth after selective caries removal.
More Related Videos
Related Concept Videos
Clinical Trials
There are four phases in a clinical trial. A phase one...
Clinical Trials: Overview
Statistical Software for Data Analysis and Clinical Trials
Oral Cavity
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
What is Natural Selection?
Trial and Error and Algorithm

