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Lou Gehrig's Disease (ALS): UBQLN2 Mutations Strike Out of Phase
Nicole Higgins1, Brian Lin1, Mervyn J Monteiro1
1The Center for Biomedical Engineering and Technology, Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Structure (London, England : 1993)
|June 6, 2019
Abstract:
In this issue of Structure, Dao et al. (2019) report that ALS-linked mutations in the Pxx domain of Ubiquilin 2 (UBQLN2) differentially influence the protein's phase separation abilities. The affect is by reducing the temperature and UBQLN2 concentration necessary for liquid-liquid phase separation droplet formation and by modulating UBQLN2 oligomerization.