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Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
Published on: September 15, 2023
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Hypocalcemia after Total Thyroidectomy in Graves Disease.
Malak Al Qubaisi1, Philip I Haigh2
1Royal College of Surgeons in Ireland, Dublin, Ireland.
The Permanente Journal
|June 7, 2019
Summary
Patients with Graves disease undergoing total thyroidectomy are twice as likely to develop hypocalcemia. This risk factor analysis identifies key predictors of postoperative hypocalcemia, informing patient care strategies.
Area of Science:
- Endocrinology
- Surgical Oncology
- Neurosurgery
Background:
- Total thyroidectomy is a definitive treatment for Graves disease.
- Hypocalcemia is a known complication following total thyroidectomy.
Purpose of the Study:
- To compare the risk of hypocalcemia after total thyroidectomy in patients with and without Graves disease.
- To identify risk factors associated with postoperative hypocalcemia.
Main Methods:
- Utilized data from the 2016 American College of Surgeons National Surgical Quality Improvement Program.
- Included 5871 patients who underwent total thyroidectomy, analyzing 2143 for hypocalcemia outcomes.
- Employed multivariable logistic regression to assess risk factors.
Main Results:
- Hypocalcemia occurred in 10.4% of patients (222/2143), with 5.8% experiencing symptomatic hypocalcemia (124/2143).
- Patients with Graves disease had a higher incidence of hypocalcemia (16.3% vs. 9.4%).
- Increased risk was associated with female sex and parathyroid autotransplantation; older age correlated with decreased risk.
Conclusions:
- Graves disease significantly increases the risk of postoperative hypocalcemia following total thyroidectomy.
- Female sex and parathyroid autotransplantation are independent risk factors for hypocalcemia.
- Older patients exhibit a lower risk of developing hypocalcemia post-thyroidectomy.
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