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Updated: Jan 23, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Squamous cell carcinoma of unknown primary origin in a dog presenting with bone metastasis
Oscar Rodrigo Sierra Matiz1, Rafaela Bortolotti Viera1, Paulo Cesar Jark1
1Clinic and Surgery Department, College of Agricultural and Veterinarian Science, São Paulo State University, UNESP 14884-900, Jaboticabal, SP, Brazil.
Abstract:
A 10-year-old female American Pit Bull dog was diagnosed with metastatic undifferentiated carcinoma of the scapula. Immunohistochemistry showed positive immunoexpression for cytokeratins (AE1/AE3, 34BE12, CK7) and vimentin, confirming squamous cell carcinoma. No evidence of nodules was found in the complete physical examination and imaging procedures conducted. The patient was diagnosed with carcinoma of unknown primary origin. Amputation and adjuvant chemotherapy with doxorubicin and piroxicam were performed, but the patient died of respiratory failure after 737 days of diagnosis. Necropsy confirmed undifferentiated carcinoma infiltrating the lungs and kidneys, and showing the same immunoexpression as the tumor in the scapula. Amputation associated with chemotherapy extended the overall survival time of this patient.
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