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THE RELATIONSHIP BETWEEN SERUM LEVEL OF MALONDIALDEHYDE AND PROGRESSION OF COLORECTAL CANCER
Ismar Rašić1, Azra Rašić1, Goran Akšamija1
11Department of General and Abdominal Surgery, Sarajevo Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina; 2Department of Oncology, Sarajevo Clinical Center, University of Sarajevo, Sarajevo, Bosnia and Herzegovina; 3Department of Pathology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Acta Clinica Croatica
|June 7, 2019
Summary
Serum malondialdehyde (MDA) levels increase with colorectal cancer (CRC) progression. Higher MDA concentrations correlate significantly with advanced CRC stages and metastasis, indicating MDA
Area of Science:
- Oncology
- Biochemistry
- Medical Diagnostics
Background:
- Colorectal cancer (CRC) is a significant global health concern.
- Biomarkers are crucial for early detection and staging of CRC.
- Oxidative stress plays a role in cancer development and progression.
Purpose of the Study:
- To evaluate serum malondialdehyde (MDA) levels in colorectal cancer (CRC) patients.
- To determine the association between serum MDA concentration and CRC stage.
- To investigate the relationship between serum MDA and histopathologic tumor size in CRC.
Main Methods:
- Cross-sectional study involving 102 CRC patients undergoing surgical treatment.
- Patients classified into stages I-IV using TNM classification.
- Serum MDA concentration measured using ELISA immunoassay in preoperative blood samples.
- Comparison with a control group of 30 healthy subjects.
Main Results:
- Serum MDA levels showed a progressive increase with advancing CRC stages.
- Significantly higher MDA levels were observed in Stage IV CRC compared to earlier stages.
- Elevated MDA concentrations correlated with larger tumor sizes (pT4 vs. pT3/pT2) and lymph node metastasis (N1/N2 vs. N0).
- MDA levels were significantly higher in patients with distant metastasis.
Conclusions:
- Serum MDA concentration is a potential indicator of CRC progression.
- Increasing MDA levels are significantly associated with advanced tumor stage, size, and metastatic disease in CRC.
- MDA may serve as a valuable biomarker in monitoring CRC advancement.
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