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EFFICACY AND SAFETY OF A SINGLE-PILL COMBINATION OF ATORVASTATIN/AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION

Stefan Naydenov Naydenov1, Nikolay Margaritov Runev1, Emil Ivanov Manov1

  • 11Prof. St. Kirkovich Department of Internal Diseases, Medical University of Sofia, Sofia, Bulgaria; 2Tokuda Hospital, Sofia, Bulgaria.

Acta Clinica Croatica
|June 7, 2019
PubMed

Insights

A single-pill combination of atorvastatin/amlodipine effectively managed arterial hypertension and dyslipidemia in high-risk patients. This treatment demonstrated significant reductions in blood pressure and cholesterol levels over three months with good tolerability.

Area of Science:

  • Cardiology
  • Pharmacology
  • Clinical Medicine

Background:

  • Arterial hypertension and dyslipidemia are key risk factors for cardiovascular disease.
  • Managing these conditions concurrently is crucial for reducing overall cardiovascular risk.
  • A single-pill combination offers a simplified therapeutic approach.

Purpose of the Study:

  • To assess the efficacy and tolerability of a fixed-dose combination of atorvastatin and amlodipine.
  • To evaluate the impact of this combination therapy on blood pressure and lipid profiles.
  • To determine the effectiveness in patients with moderate to high cardiovascular risk.

Main Methods:

  • Prospective study involving 243 patients.
  • Patients received atorvastatin/amlodipine in doses of 10/5, 10/10, 20/5, or 20/10 mg daily.
  • Follow-up duration was 3 months.

Main Results:

  • Significant reductions in systolic blood pressure (155.7 to 136.9 mm Hg) and diastolic blood pressure (92.0 to 80.6 mm Hg).
  • Significant reductions in total cholesterol (6.6 to 5.1 mmol/L) and LDL cholesterol (4.4 to 2.9 mmol/L).
  • Adverse events led to discontinuation in only 3.7% of patients.

Conclusions:

  • The single-pill combination of atorvastatin/amlodipine is effective in treating patients with hypertension and dyslipidemia.
  • This combination therapy is well-tolerated in patients at moderate to high cardiovascular risk.
  • Simplified treatment regimens can improve adherence and outcomes in cardiovascular disease management.

Keywords:
Antihypertensive agentsCardiovascular diseasesDyslipidemiasHypertension

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