Related Experiment Videos
Ovarian stimulation, including in vitro fertilisation
P Devroey1, A Wisanto, J Smitz
1Centre for Reproductive Medicine, University Hospital and Medical School Brussels, Belgium.
Annales De Biologie Clinique
|January 1, 1987
Summary
Ovulation induction in anovulatory and Luteinized Unruptured Follicle (LUF) syndrome patients shows acceptable multiple pregnancy rates. Pregnancy rates are lower in LUF patients, requiring further research into the syndrome and hormonal interactions.
Area of Science:
- Reproductive endocrinology
- Infertility research
Background:
- Anovulatory infertility and Luteinized Unruptured Follicle (LUF) syndrome are common challenges in assisted reproduction.
- Ovulation induction and superovulation protocols are crucial for improving pregnancy rates in these patients.
Purpose of the Study:
- To discuss stimulation regimens and outcomes for ovulation induction in anovulatory patients and those with LUF syndrome.
- To analyze superovulation findings in In Vitro Fertilization (IVF) cycles.
- To investigate the reduced luteinizing hormone (LH) surges in stimulated cycles.
Main Methods:
- Review of stimulation regimens and patient outcomes.
- Hormonal determinations for monitoring ovulation induction.
- Comparison of pregnancy rates between anovulatory patients and LUF syndrome patients.
Main Results:
- Acceptable multiple pregnancy rates (≤20%) achieved with accurate daily hormonal monitoring.
- Lower pregnancy rates observed in the LUF population compared to anovulatory patients.
- Reduced maximum serum LH concentration in stimulated cycles versus natural cycles, despite multiple oocyte maturation.
Conclusions:
- The pathophysiology of LUF syndrome remains largely unknown, contributing to lower pregnancy rates.
- Increased inhibin-like substances may explain reduced LH surges in stimulated cycles.
- Further research is needed to elucidate the interaction between the follicle and the hypothalamic-hypophysial axis in stimulated cycles.