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Anaphylaxis from biologicals is a serious adverse event. This review covers phenotypes and management strategies for these immune reactions to biologic therapies.

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Area of Science:

  • Immunology
  • Pharmacology
  • Oncology

Background:

  • Therapeutic biologicals are increasingly used for cancer and inflammatory conditions.
  • Biological agents can cause severe adverse events, including hypersensitivity reactions like anaphylaxis.
  • Understanding these reactions is crucial due to the rising use of biologics.

Purpose of the Study:

  • To review the current understanding of anaphylaxis induced by biological agents.
  • To discuss the spectrum of hypersensitivity reactions to biologics.
  • To provide insights into the diagnosis and management of anaphylaxis from biologics.

Main Methods:

  • Literature review of anaphylaxis associated with biological therapies.
  • Analysis of reported phenotypes and endotypes of hypersensitivity reactions.
  • Synthesis of current knowledge on management strategies.

Main Results:

  • Anaphylactic reactions to biologics present with diverse phenotypes, ranging from IgE-mediated to cytokine release syndromes.
  • Reactions can be immediate or delayed, involving complex immunological mechanisms.
  • Management approaches should be tailored to specific reaction phenotypes.

Conclusions:

  • Further research is needed to define immediate adverse reactions and identify diagnostic biomarkers for biologicals.
  • Improved understanding will enhance the immediate and long-term management of patients receiving biologic therapies.
  • Tailored management based on reaction phenotype is essential for patient safety.