[Systemic membrane-destabilizing distress syndrome in surgery: concept, pathogenesis, diagnosis]

Area of Science:

• Surgical pathology
• Cellular biology
• Biochemistry

Background:

• Acute abdominal diseases are associated with significant cellular dysfunction.
• Understanding the molecular mechanisms underlying these conditions is crucial for improving patient care.

Purpose of the Study:

• To investigate the role of cell membrane phospholipid bilayers in acute abdominal diseases.
• To establish the concept of systemic membrane-destabilizing distress syndrome in surgical patients.

Main Methods:

• Experimental studies in dogs (n=90) and clinical studies in patients (n=119) with various acute abdominal conditions.
• Analysis of lipid profiles, lipid peroxidation, phospholipase activity, and endogenous intoxication.
• Assessment of organ and blood cell function.

Main Results:

• Acute abdominal diseases induce significant alterations in the phospholipid bilayer of cell membranes across multiple organs.
• These membrane changes correlate with disease severity and progression.
• A novel concept, systemic membrane-destabilizing distress syndrome, was identified and characterized.

Conclusions:

• Systemic membrane-destabilizing distress syndrome is a critical factor in the pathogenesis of acute abdominal diseases and surgical aggression.
• The findings provide a new framework for understanding and diagnosing complex surgical conditions.
• Further research into membrane stabilization may offer therapeutic targets.