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Remotely controlled nanofluidic implantable platform for tunable drug delivery
Nicola Di Trani1, Antonia Silvestri, Giacomo Bruno
1Nanomedicine Department, Houston Methodist Research Institute, Houston, TX, USA. agrattoni@houstonmethodist.org.
Lab on a Chip
|June 7, 2019
Summary
This study introduces a novel implantable device for chronic disease management. It allows remote, adjustable drug delivery, improving treatment personalization and adherence for conditions like hypertension and rheumatoid arthritis.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Drug Delivery Systems
Background:
- Chronic diseases necessitate lifelong management, but adherence to strict dosing schedules is challenging.
- Current treatments often fail to account for individual patient variability.
- Existing implantable devices lack flexible dosage and timing control.
Purpose of the Study:
- To develop a subcutaneously implantable, remote-controlled nanofluidic device for personalized drug delivery.
- To enable adjustable and on-demand administration of therapeutics for chronic conditions.
- To overcome limitations of conventional drug delivery systems in chronic disease management.
Main Methods:
- Development of a nanofluidic device controlled by a low-intensity electric field via Bluetooth.
- In vitro modulation of enalapril (hypertension) and methotrexate (rheumatoid arthritis) release rates.
- In vivo assessment of remote communication and device biocompatibility.
Main Results:
- Demonstrated in vitro control over drug release rates (increase, decrease, stop) for enalapril and methotrexate.
- Confirmed reliable remote communication and biocompatibility of the implantable device in vivo.
- The device enables continuous drug administration, avoiding abrupt fluctuations.
Conclusions:
- The developed nanofluidic device offers a flexible, remote-controlled solution for personalized chronic disease management.
- This technology has the potential to improve therapeutic efficacy and patient adherence.
- It lays the groundwork for a new platform for on-demand drug delivery systems.
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