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Updated: Jan 23, 2026

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
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Bioprinters for organs-on-chips.

Amir K Miri1, Ebrahim Mostafavi2, Danial Khorsandi3,4

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Bioprinting technologies rapidly create organ-on-chip models and biomimetic tissues. These advancements enable sophisticated control and observation for drug development and pathological studies.

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Area of Science:

  • Biotechnology
  • Tissue Engineering
  • Microfluidics

Background:

  • Recent advances in bioprinting enable rapid manufacturing of organ-on-chip (OOC) models.
  • Bioprinting integrates microfluidic channels and flow connections within OOC models.
  • Bioprinting facilitates the creation of biomimetic tissue microarchitectures.

Purpose of the Study:

  • To review nozzle-based and optical-based bioprinters.
  • To discuss fabrication parameters including resolution, replication fidelity, fabrication time, and cost.
  • To highlight applications in micro-tissue models and microfluidic systems.

Main Methods:

  • Review of current bioprinting technologies.
  • Categorization of bioprinters into nozzle-based and optical-based methods.
  • Analysis of fabrication parameters relevant to micro-scale applications.

Main Results:

  • Bioprinters successfully replicate functional engineered tissue models within microfluidic systems.
  • Integration allows for observation of model metabolism and secretion.
  • Enables sophisticated control of dynamic environments for biological studies.

Conclusions:

  • Bioprinting offers advanced fabrication for tissue engineering.
  • Mimicking physiological conditions enhances applications in drug development and pathological studies.
  • Bioprinting is a key technology for creating complex, functional micro-tissue models.