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Updated: Jan 23, 2026

Introducing Clicker Training as a Cognitive Enrichment for Laboratory Mice
Published on: March 6, 2017
Studying Laboratory Mice - Into the Wild
Julie C Savage1, Marie-Ève Tremblay1
1Neurosciences Axis, Centre de recherche du CHU de Québec, 2705 Boulevard Laurier, Québec, G1V 4G2, Canada.
Abstract:
Studies using rewilded laboratory mice have begun to provide important clues into the complex relationship between environment, immunity, and behavior. In a recent paper, Cope and colleagues (Hippocampus, 2019) showed that exposing laboratory mice to outdoor living, either with or without peripheral worm infection, increased adult neurogenesis and had major effects on microglia, but only outdoor living coupled with worm infection increased anxiety.
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