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Acquired haemophilia and rheumatoid arthritis
R M Soriano1, J M Matthews, E Guerado-Parra
1Nuffield Department of Orthopaedic Surgery, University of Oxford, Headington, UK.
British Journal of Rheumatology
|October 1, 1987
Abstract:
Four patients with classical rheumatoid arthritis who developed acquired haemophilia are described. They developed a spontaneous bleeding diathesis and diagnosis was based on low or absent Factor VIII levels and the presence of a circulating anticoagulant directed against Factor VIII. The course is variable and cyclophosphamide together with control of the underlying rheumatoid arthritis are recommended as treatment.