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Related Experiment Video

Updated: Jan 23, 2026

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Published on: April 28, 2023

Regenerative and engineered options for urethroplasty.

Filippo Pederzoli^1,2,3, Gregory Joice², Andrea Salonia^1,3

¹Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Nature Reviews. Urology

|June 8, 2019

Summary

Tissue engineering offers a promising alternative to traditional urethroplasty for urethral stricture repair. While advances show potential, engineered tissues are not yet standard care for urethral reconstruction.

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Last Updated: Jan 23, 2026

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model

Published on: April 28, 2023

Harmonic Nanoparticles for Regenerative Research

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Published on: May 1, 2014

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

3D Microtissues for Injectable Regenerative Therapy and High-throughput Drug Screening

Published on: October 4, 2017

Area of Science:

Regenerative Medicine
Urology
Biomaterials Science

Background:

Substitution urethroplasty for urethral strictures presents significant surgical challenges, often leading to restenosis and reduced quality of life.
Current surgical techniques have limitations, highlighting the need for innovative treatment strategies.

Purpose of the Study:

To explore tissue engineering as a viable alternative for urethral repair and replacement.
To review the progress and clinical potential of tissue-engineered therapies for urethral reconstruction.

Main Methods:

Review of advancements in tissue engineering, focusing on cell types and scaffold development for urethral applications.
Analysis of existing clinical data and applications of tissue engineering in urethral replacement.

Main Results:

Tissue engineering has successfully yielded clinical therapies for cutaneous, bone, and cartilage defects over the past 30 years.
Early clinical applications of tissue-engineered urethral replacements demonstrate promising outcomes.

Conclusions:

Tissue engineering presents a promising avenue for addressing the limitations of current urethral stricture treatments.
Despite promising advances, tissue-engineered urethral replacement has not yet achieved standard of care status.