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Updated: Jan 23, 2026
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Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
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[Chronic relapsing inflammatory optic neuropathy: a literature review]
J V Hervas-Garcia1, F Pagani-Cassara2,3
1Hospital Universitari Arnau de Vilanova , Lleida, Espana.
Revista De Neurologia
|June 8, 2019
Summary
Chronic relapsing inflammatory optic neuropathy (CRION) is a rare, recurrent optic nerve condition. Early diagnosis and accurate treatment are crucial for improving patient prognosis in this steroid-dependent disease.
Area of Science:
- Neuro-ophthalmology
- Inflammatory diseases
- Autoimmune disorders
Background:
- Chronic relapsing inflammatory optic neuropathy (CRION) is an inflammatory condition.
- Characterized by recurrent optic neuritis episodes with steroid responsiveness and relapse upon withdrawal.
Purpose of the Study:
- To conduct a systematic literature review on CRION from 2003 to the present.
- Focus on adult human research, excluding pediatric or animal studies.
Main Methods:
- Systematic literature search using terms like CRION, recurrent optic neuritis, and steroid-dependent optic neuritis.
- Analysis of studies focusing on etiology, presentation, differential diagnoses, and treatment.
Main Results:
- CRION is a relapsing optic neuritis of unknown cause, presenting with severe visual loss.
- Strong corticosteroid response suggests an immune-mediated mechanism.
- Differential diagnoses include demyelinating, systemic, and infectious diseases.
Conclusions:
- CRION is a rare, recurrent, and cortico-dependent optic nerve disease.
- Early diagnosis and accurate treatment are essential for a better prognosis.
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