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Beta-lactamase alteration of beta-lactam inhibitory zones
1Department of Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
European Journal of Clinical Microbiology
|August 1, 1987
Abstract:
A disk approximation test, in which the inhibitory zone of one beta-lactam antibiotic is truncated under influence of another beta-lactam (e.g. cefoxitin), was used as a screen for the presence of inducible beta-lactamase. By using beta-lactamase extracts and a specific inhibitor, it was shown that chromosomal beta-lactamase can indeed be the sole cause of truncated beta-lactam inhibitory zones.