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Updated: Jan 23, 2026

Quantifying Agonist Activity at G Protein-coupled Receptors
Published on: December 26, 2011
Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata
Si-Yue Chen1,2, Chang-An Geng1, Yun-Bao Ma1
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming, 650201, China.
Abstract:
Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1-3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT1 and MT2 receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC50 value of 76.24 μM on MT2 receptor.
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