General-purpose passive wireless point-of-care platform based on smartphone

Area of Science:

• Analytical Chemistry
• Biomedical Engineering
• Electrical Engineering

Background:

• Point-of-care testing (POCT) requires accessible, low-cost analytical devices.
• Existing POCT platforms often lack versatility and smartphone integration.
• Smartphone-based analytical systems offer potential for remote diagnostics and data sharing.

Purpose of the Study:

• To design, test, and validate a compact, low-cost analytical platform for POCT.
• To integrate electrochemical and electrochemiluminescence techniques with smartphone control.
• To demonstrate the platform's utility for determining clinically relevant analytes.

Main Methods:

• Development of a passive measurement system powered by a smartphone.
• Utilization of screen-printed electrodes and off-the-shelf electronic components.
• In-depth study of power, electrical, and optical signal processing.
• Validation using amperometric, potentiometric, cyclic voltammetry, and electrochemiluminescent techniques.

Main Results:

• The platform achieves energy harvesting up to 22.5 µW and voltage control of ±1.15 V.
• Accurate potential and current measurements were demonstrated with high resolution.
• Analytical techniques showed excellent agreement with a reference instrument.
• Successful determination of glucose, H2O2, and pH with clinically relevant ranges and low limits of detection.

Conclusions:

• The developed analytical platform is versatile, compact, and cost-effective (
• Smartphone integration enables easy configuration, data processing, and wireless sharing.
• The platform is suitable for various analytical applications in point-of-care settings.