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Electrically conductive nanomaterials for cardiac tissue engineering
Khadijeh Ashtari1, Hojjatollah Nazari2, Hyojin Ko3
1Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran; Faculty of Advanced Technologies in Medicine, Department of Medical Nanotechnology, Iran University of Medical Sciences, Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Advanced Drug Delivery Reviews
|June 10, 2019
Summary
Electrically conductive nanomaterials show promise for cardiac tissue engineering. These advanced materials can improve engineered scaffolds, potentially aiding in the repair of heart tissue damaged by myocardial infarction.
Area of Science:
- Biomedical Engineering
- Materials Science
- Regenerative Medicine
Background:
- Cardiovascular diseases are a leading cause of death globally, with myocardial infarction causing irreversible cardiomyocyte loss and heart failure.
- Myocardial infarction leads to scar formation, disrupting heart structure and causing arrhythmias.
- Tissue engineering offers potential solutions for cardiac tissue repair through engineered scaffolds.
Purpose of the Study:
- To review the application of electrically conductive nanomaterials in cardiac tissue engineering scaffolds.
- To summarize the impact of these nanomaterials on cardiac cell behavior and stem cell differentiation.
Main Methods:
- Review of recent literature on nanomaterial-based cardiac tissue engineering.
- Focus on carbon-based nanomaterials, gold-based nanomaterials, and electroactive polymers.
- Analysis of studies investigating nanomaterial effects on cell proliferation, migration, and cardiomyogenic differentiation.
Main Results:
- Electrically conductive nanomaterials are being increasingly used in engineered cardiac scaffolds.
- These nanomaterials influence cardiac cell proliferation and migration.
- Nanomaterials impact the cardiomyogenic differentiation of stem cells.
Conclusions:
- Electrically conductive nanomaterials represent a promising avenue for developing advanced cardiac tissue engineering scaffolds.
- Further research into these materials could lead to improved treatments for heart conditions resulting from myocardial infarction.
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