Intraoperative real-time guidance using ShearWave Elastography for epilepsy surgery

In epilepsy surgery, seizure outcome is determined by the integrity of epileptogenic zone resection. ShearWave elastography (SWE) is a noninvasive imaging technique that generates a quantitative assessment of elasticity values permitting intraoperative real time tissue mapping by differentiating normal and pathological epileptogenic tissue. The aim of this study was to evaluate the contribution of SWE intraoperative guidance on the advancement of epileptogenic zone detection in epilepsy surgery.

We prospectively analyzed epileptogenic zone resections using SWE guidance for 28 patients with severe and/or disabling drug-resistant focal epilepsy.

Conventional B-mode images visualized echogenicity differences between the epileptogenic lesion and normal brain tissue in 71.4% of cases, while SWE detected a significant difference in stiffness in 92.8% of cases (p = 0.02). Regarding cryptogenic epilepsy, none of the 4 MRI-negative focal cortical dysplasias was visualized by B-mode images, while 3 cases were detected by SWE. Postoperative brain MRI showed a complete resection of the epileptogenic zone in all MRI-positive cases. One year after the surgery, 85.7% of the patients were seizure free (ILAE class 1).

Despite some technical limitations, SWE improves the intraoperative detection of epileptogenic lesions and should be considered for all patients with cryptogenic and lesional epilepsy. Naturally this ought to be confirmed by larger case series additionally investigating long-term seizure outcome.