Cell intrinsic hallmarks (Frequency and Bioelectrical potential) sensitive nano-carriers for cancer therapy: A lost...

Bioelectric potential and frequency parameters, unlike temperature and pH are not affected by environmental factors. Independence of these parameters and their dependence on cellular interactions eliminates interfering factors and increases the accuracy of direct drug delivery. To the best of our knowledge, both parameters of bioelectric potential and the frequency which is produced from cellular activity have not been used as a target for targeted drug delivery. Based on the available evidence, we propose that the frequency and bioelectricity from normal cells with tumor cells and tumors together demonstrate a good level of distinction in order to target proposed cell for drug delivery. Applying this feature as a means of distinguishing between normal and tumor cells and utilizing nanotechnology in the design and production of nano-carriers based on sensitivity to frequency or bioelectric potential and adjustable as alternatives for temperature and pH in purpose of targeted drug delivery with the maximum level of efficiency. Our proposed method of frequency/bioelectric potential-based drug delivery can significantly reduce damages and medication side effects to normal cell by improving drug delivery to tumor cells. It can be an important development in the prevention of expanding tumor cells and enhancement treatment of cancer.