Cross-Linked Poly(ethylene glycol) Shells for Nanoparticles: Enhanced Stealth Effect and Colloidal Stability.
Dianqi Li1, Fengchao Wang1, Huixia Di1
1College of Chemistry, Research Center for Analytical Sciences, State Key Laboratory of Medicinal Chemical Biology, and Tianjin Key Laboratory of Molecular Recognition and Biosensing , Nankai University , Tianjin 300071 , China.
Langmuir : the ACS Journal of Surfaces and Colloids
|June 11, 2019
Summary
Cross-linking poly(ethylene glycol) shell-wrapped gold nanoparticles (Au@CL-PEG NPs) effectively prevent protein adsorption and reduce macrophage uptake. This novel CL-PEGylation strategy enhances nanomedicine performance and stability.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Protein corona formation and macrophage uptake hinder nanocarrier efficiency.
- Developing advanced nanocarriers with improved stealth properties is crucial for effective drug delivery.
Purpose of the Study:
- To develop and evaluate cross-linking poly(ethylene glycol) (CL-PEG) shell-wrapped gold nanoparticles (Au@CL-PEG NPs) for enhanced nanomedicine applications.
- To assess the stealth effect, colloidal stability, and protein adsorption resistance of Au@CL-PEG NPs compared to conventional PEGylated nanoparticles.
Main Methods:
- Synthesis of gold nanoparticles (AuNPs) coated with cross-linking poly(ethylene glycol) (CL-PEG).
- Comparison of Au@CL-PEG NPs with conventional linear PEG-coated AuNPs (Au@PEG NPs) regarding protein adsorption and cellular uptake by macrophages.
- Evaluation of chemical and colloidal stability under various extreme conditions.
Main Results:
- Au@CL-PEG NPs demonstrated a significantly enhanced ability to resist protein adsorption compared to Au@PEG NPs.
- Reduced cellular uptake by macrophages was observed for Au@CL-PEG NPs.
- Au@CL-PEG NPs exhibited superior chemical and colloidal stability under diverse extreme conditions.
Conclusions:
- The CL-PEGylation strategy offers a promising approach for surface functionalization of nanomaterials.
- Au@CL-PEG NPs show great potential for developing high-performance nanomedicines with improved delivery efficiency and stability.
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