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The clinical application of fruquintinib on colorectal cancer

Zhongguang Chen1, Lili Jiang2

  • 1a Department of Pharmaceutical, Central Hospital of Linyi City , Yishui , Shandong , China.

Expert Review of Clinical Pharmacology
|June 11, 2019
PubMed

Insights

Fruquintinib is a new VEGFR inhibitor approved for colorectal cancer treatment. It shows advantages in efficacy and safety, offering a potential third-line therapy option.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Anti-angiogenic agents targeting EGFR, VEGF, and VEGFRs are standard for colorectal cancer (CRC).
  • Fruquintinib, a selective VEGFR inhibitor, is approved in China for CRC treatment, demonstrating clinical advantages.

Purpose of the Study:

  • To review the molecular aspects, pharmacokinetics, clinical efficacy, and safety of fruquintinib.
  • To explore potential applications of fruquintinib in non-small cell lung cancer (NSCLC) and gastric cancer.

Main Methods:

  • Detailed review of existing literature on fruquintinib.
  • Analysis of clinical trial data regarding efficacy and safety profiles.

Main Results:

  • Fruquintinib exhibits high selectivity for VEGFRs (1, 2, and 3) with low off-target toxicity.
  • Clinical studies indicate good drug tolerance and significant efficacy in CRC patients.

Conclusions:

  • Fruquintinib is approved as a third-line therapy for metastatic colorectal cancer (RAS wild type) patients.
  • Combination therapy with fruquintinib may overcome drug resistance and enhance treatment outcomes in CRC.
Keywords:
CRCEGFRFruquintinibVEGFVEGFR

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