Related Experiment Video
Updated: Aug 13, 2026

Population Replacement Strategies for Controlling Vector Populations and the Use of Wolbachia pipientis for Genetic Drive
Published on: July 4, 2007
"Running the Gauntlet": Formidable challenges in advancing neglected tropical diseases vaccines from development
Maria Elena Bottazzi1,2, Peter J Hotez1,2,3,4
1Texas Children's Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine , Houston , TX , USA.
Abstract:
Translational science for new biotechnologies (e.g. drugs, vaccines, devices, or diagnostics) depend on the development of a robust '. This is driven by complex scientific, technical, logistical, financial and operational elements to determine the feasibility and probability of traversing the "valleys of death" leading to licensure. The potential results in terms of profitability and financial realization, called play a crucial role in establishing incentives for investment during and after development. With this review, our goal is to summarize the challenges in taking vaccines against neglected tropical diseases (NTDs) from development through licensure and provide a perspective that these vaccines can have measurable public health and economic profitability and market success. Understanding these processes and its challenges would open the opportunity to accelerate and advance these essential NTD vaccines through the last mile towards licensure and for the delivery to afflicted populations in low- and middle-income countries.
Related Concept Videos
Vaccinations
Microorganisms in Medicine and Therapeutics
Vaccine Production
Infectious Diseases and Their Occurrence
Vaccines
Toxoplasmosis

