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Clinically relevant allergens from laboratory and domestic small animals
1Department of Pediatrics, University of Arizona Health Sciences Center, Tucson 85724.
New England and Regional Allergy Proceedings
|July 1, 1987
Summary
Animal allergens, often acidic proteins, are found in urine and saliva, not just dander. These include allergens from mice, rats, and cats, important for allergy diagnosis and treatment.
Area of Science:
- Immunology
- Allergen characterization
- Protein biochemistry
Background:
- Major animal allergens are typically acidic proteins.
- Urine and saliva are significant sources of animal allergens, alongside epithelia.
- Allergens from mice, rats, guinea pigs, rabbits, and cats have been identified.
Purpose of the Study:
- To highlight the importance of urine and saliva as sources of animal allergens.
- To discuss the identification and standardization of key animal allergens.
- To emphasize the potential for improved allergy diagnosis and immunotherapy.
Main Methods:
- Protein isolation and characterization.
- Immunochemical analysis of animal-derived antigens.
- Air sampling to detect airborne allergens.
Main Results:
- Urinary protein allergens identified in mice, rats, guinea pigs, and rabbits.
- Cat saliva contains all major allergens found in cat pelt extract.
- Airborne allergens from mice, rat, and cat urine/saliva detected in inhabited rooms.
Conclusions:
- Urine and saliva are critical sources for major animal allergens.
- Standardized allergens from mice, rats, and cats are feasible for clinical applications.
- Further research can advance immunotherapeutic strategies for animal allergies.