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[Gonadotropin secretion in children with galactosemia]
E Schober1, S Scheibenreiter, H Frisch
1Universitäts-Kinderklinik Wien.
Abstract:
Basal and stimulated gonadotropin levels were evaluated in 8 children with galactosemia (2 boys, 6 girls). 5 girls demonstrated increased gonadotropin concentrations being in accordance with hypergonadotropic hypogonadism. It appears, that galactose and its metabolites-either dietary or by self-intoxication-exerts a toxic effect on the ovarian parenchyma, whereas the testis seems to be resistant to the damaging agent.