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Updated: Jan 23, 2026

Field Postmortem Rabies Rapid Immunochromatographic Diagnostic Test for Resource-Limited Settings with Further Molecular Applications

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Published on: June 29, 2020

Pitfalls in molecular diagnostics.

Lulu Sun¹, John D Pfeifer¹

¹Pathology and Immunology Department, Washington University School of Medicine, 660 S. Euclid Ave., Box 8118, St. Louis, MO 63110, United States.

Seminars in Diagnostic Pathology

|June 12, 2019

Summary

This summary is machine-generated.

Molecular diagnostic tests, including immunohistochemistry and sequencing, are vital for pathologists. Understanding their potential pitfalls and emerging technologies is crucial for accurate interpretation and improved patient care.

Keywords:

Chromosomal microarray Immunohistochemistry Microsatellite instability Molecular diagnostics Next-generation sequencing

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Area of Science:

Pathology
Molecular Biology
Genetics

Background:

Molecular diagnostic techniques are essential tools for anatomic pathologists.
Technological advancements and increased understanding of disease pathogenesis drive assay development.
Improper application or interpretation of these tests can lead to significant errors.

Purpose of the Study:

To review commonly used molecular diagnostic tests.
To highlight potential pitfalls and considerations for each testing platform.
To discuss emerging molecular technologies for future clinical use.

Main Methods:

Review of existing literature on molecular diagnostic techniques.
Analysis of immunohistochemistry, microsatellite instability testing, chromosomal microarray testing, and sequencing (conventional and next-generation).
Discussion of emerging molecular technologies.

Main Results:

Each molecular platform has specific challenges in execution and interpretation.
Understanding methodologies, advantages, and drawbacks is key to accurate results.
Emerging technologies show promise for future clinical applications.

Conclusions:

Pathologists must be aware of the limitations and proper application of molecular assays.
Comprehensive knowledge of molecular diagnostic platforms aids in diagnostic and therapeutic decision-making.
Continuous learning regarding new molecular technologies is essential for modern pathology practice.