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Updated: Jan 23, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Vascular endothelial growth factor gene polymorphisms in patients with rosacea: A case-control study
Yıldız Hayran1, Incilay Lay2, Mehmet Cem Mocan3
1Department of Dermatology, Hacettepe University School of Medicine, Ankara, Turkey.
Background:
Rosacea is a chronic disease that is characterized by facial skin inflammation and vascular abnormality. Vascular endothelial growth factor (VEGF) is a potent mediator of vascular permeability and inflammation that might play a role in the pathogenesis of rosacea.
Objective:
This study aimed to determine the association between VEGF gene polymorphisms and rosacea.
Methods:
A case-control study design was used to compare 100 patients with rosacea and 100 age- and gender-matched control subjects in terms of VEGF polymorphisms based on polymerase chain reaction and the serum level of VEGF and VEGF receptors based on enzyme-linked immunosorbent assay.
Results:
Heterozygous and homozygous +405C/G polymorphism of the VEGF gene was observed to increase the risk of rosacea 1.7-fold (95% confidence interval 1.2-4.2) and 2.3-fold (95% confidence interval 1.2-4.2), respectively. There was a significant positive correlation between the severity of rosacea and +405C/G polymorphism of the VEGF gene in patients with erythematotelangiectatic rosacea.
Limitations:
Serum VEGF and VEGF receptor levels were measured in the limited number of patients.
Conclusion:
The present findings indicate that +405C/G polymorphism of the VEGF gene increases the risk of rosacea.
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