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Updated: Jan 23, 2026

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
Published on: September 9, 2015
Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus
Marissa Lindman1, Thomas Dick2
1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Abstract:
The β-lactams imipenem and cefoxitin are used for the treatment of Mycobacterium abscessus lung infections. Here, we show that these cell wall synthesis inhibitors trigger a lethal bacterial ATP burst by increasing oxidative phosphorylation. Cotreatment of M. abscessus with the antimycobacterial ATP synthase inhibitor bedaquiline suppresses this ATP burst and eliminates the bactericidal activity of β-lactams. Thus, the addition of bedaquiline to β-lactam-containing regimes may negatively affect treatment outcome.
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