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Related Experiment Videos

Four methods to recruit renal functional reserve.

H Mansy1, D Patel, J S Tapson

  • 1Department of Medicine, Freeman Hospital, Newcastle upon Tyne, UK.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1987
PubMed
Summary
This summary is machine-generated.

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Dietary protein intake significantly impacts kidney function. Both acute protein intake and chronic high-protein diets increase creatinine clearance, suggesting a role for protein in measuring maximal filtration capacity.

Area of Science:

  • Nephrology
  • Renal Physiology
  • Nutrition Science

Background:

  • Kidney function, specifically creatinine clearance (Ccr), can be influenced by dietary protein intake.
  • Previous studies have explored acute responses to protein stimuli, but comprehensive analysis of chronic effects and comparisons between protein sources is warranted.

Purpose of the Study:

  • To investigate the acute effects of intravenous amino acids and oral protein meals on Ccr in healthy subjects.
  • To evaluate the chronic impact of low- versus high-protein diets on Ccr, para-aminohippurate clearance (CPAH), inulin clearance (Cin), and plasma renin activity (PRA).
  • To compare the effects of meat and milk proteins on Ccr and to assess the role of renin in protein-induced changes in glomerular filtration.

Main Methods:

  • Acute study: Measured Ccr following intravenous amino acid infusion and oral intake of 80g meat or milk protein.

Related Experiment Videos

  • Chronic study: Measured CPAH, Ccr, Cin, and PRA in healthy subjects after 1 week on a low-protein diet (0.7 g/kg/day) and 1 week on a high-protein diet (2.0 g/kg/day).

    • Main Results:

    • Acute protein stimuli (amino acids, meat, milk) induced similar increases in Ccr (approx. 12-20%).
    • Chronic high-protein diet significantly increased Ccr (21%), Cin (26%), CPAH (8%), and filtration factor (14%) compared to a low-protein diet.
    • Plasma renin activity (PRA) increased by 43% on the high-protein diet.
    • Meat and milk proteins caused comparable changes in Ccr.

    Conclusions:

    • An 80g oral protein meal appears sufficient to elicit a maximal acute increase in Ccr, useful for assessing maximal filtration capacity.
    • Milk protein does not appear to be a dietary substitute for meat protein in reducing glomerular hyperfiltration.
    • Renin, potentially via angiotensin II, may contribute to increased glomerular filtration rate and filtration fraction following high protein intake.