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09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
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Carbapenem-Resistant Enterobacteriaceae in Solid Organ Transplantation: Management Principles
Olivia Smibert1,2, Michael J Satlin3, Anoma Nellore4
1Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, VIC, Australia.
Current Infectious Disease Reports
|June 12, 2019
Summary
Solid organ transplant recipients face higher risks of carbapenem-resistant Enterobacteriaceae (CRE) infections. Newer treatments show promise but require more clinical data for these challenging infections.
Area of Science:
- Infectious Diseases
- Transplantation Medicine
- Antimicrobial Resistance
Background:
- Carbapenem-resistant Enterobacteriaceae (CRE) pose a global health threat.
- Solid organ transplant (SOT) recipients are at increased risk for CRE acquisition, colonization, and infection due to immunosuppression and healthcare exposure.
- Outcomes for CRE infections are generally worse in SOT patients compared to non-transplant individuals.
Purpose of the Study:
- To review the epidemiology of CRE in SOT recipients.
- To discuss management principles for CRE in the context of SOT.
- To evaluate emerging therapeutic options for CRE infections in immunosuppressed patients.
Main Methods:
- Literature review of CRE epidemiology in SOT.
- Analysis of current and emerging treatment strategies for CRE.
- Discussion of infection prevention and control measures.
Main Results:
- CRE infections are a growing concern in SOT, with donor-derived infections presenting unique challenges.
- Newer antimicrobial agents show in vitro activity against various carbapenemases, but clinical data in SOT patients are limited.
- Combination therapies and novel approaches like fecal microbiota transplantation are being explored.
Conclusions:
- CRE infections in SOT recipients are difficult to treat and prevent.
- Robust infection control is critical, especially concerning donor-derived CRE.
- Emerging therapies offer hope, but further clinical validation is essential to improve outcomes.
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