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Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
Published on: September 19, 2020
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Light-Induced Redox-Responsive Smart Drug Delivery System by Using Selenium-Containing Polymer@MOF Shell/Core
Zheng Luo1, Lu Jiang2, Shaoxiong Yang3
1Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Advanced Healthcare Materials
|June 12, 2019
Summary
This study introduces novel light-responsive nanoparticles combining selenium polymers and metal-organic frameworks for precise drug delivery. These nanoparticles enable combined chemotherapy and photodynamic therapy for improved tumor treatment.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Nonspecific toxicity of chemotherapeutics necessitates advanced drug delivery systems for tumor treatment.
- Controllable drug release is crucial for enhancing therapeutic efficacy and minimizing side effects.
- Combining chemotherapy with photodynamic therapy offers a synergistic approach to cancer treatment.
Purpose of the Study:
- To design and synthesize novel laser-responsive nanoparticles for controllable drug delivery.
- To develop a shell-core nanocarrier system utilizing redox-responsive selenium-substituted polymers and photosensitive metal-organic frameworks.
- To investigate the potential of these nanoparticles for combined chemotherapy and photodynamic therapy.
Main Methods:
- Synthesis of poly(DH-Se/PEG/PPG urethane) via random polymerization of redox cleavable di-(1-hydroxylundecyl) selenide (DH-Se), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG).
- Coating of porphyrin zirconium metal-organic frameworks (PCN-224 MOF) with the synthesized polymer to form shell-core nanoparticles using an emulsion approach.
- Loading of doxorubicin (DOX) into the poly(DH-Se/PEG/PPG urethane)@MOF nanoparticles.
- Evaluation of drug release kinetics and therapeutic efficacy under laser irradiation.
Main Results:
- Spherical poly(DH-Se/PEG/PPG urethane)@MOF nanoparticles were successfully synthesized.
- The nanoparticles exhibited fast and controllable release of encapsulated doxorubicin (DOX) upon laser irradiation.
- Light-triggered reactive oxygen species (ROS) production by the MOF core led to the cleavage of the polymer shell, facilitating drug release.
- Demonstrated potential for combined chemotherapy and photodynamic therapy.
Conclusions:
- This work presents the first design of controllable drug release carriers utilizing metal-organic frameworks (MOF) and selenium-substituted polymers.
- The developed nanoparticles offer a promising platform for precise combination therapy in tumor treatment.
- The laser-responsive nature of the system allows for targeted drug delivery and enhanced therapeutic outcomes.
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