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Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
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Asymmetric Catalysis Using Chiral Salen-Metal Complexes: Recent Advances
1Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States.
Chemical Reviews
|June 12, 2019
Summary
Chiral salen-metal complexes are versatile catalysts for asymmetric synthesis, inducing high stereoinduction in various chemical reactions. This review highlights their developments and applications in organic synthesis over the past two decades.
Area of Science:
- Catalysis and Organic Synthesis
- Materials Chemistry
Background:
- Chiral salen-metal complexes are highly versatile asymmetric catalysts.
- They are utilized in diverse fields including materials chemistry and organic synthesis.
- These complexes can induce chirality with high stereoinduction in reaction products.
Purpose of the Study:
- To review developments in chiral salen-metal catalysis over the last two decades.
- To emphasize applications of importance in asymmetric synthesis.
Main Methods:
- Review of literature on chiral salen-metal complexes.
- Focus on catalytic applications in asymmetric synthesis.
Main Results:
- Salen ligands offer tunable steric and electronic properties.
- Coordination with various metals results in broad utility.
- Significant advancements in chiral salen-metal catalysis have been made.
Conclusions:
- Chiral salen-metal complexes are crucial for asymmetric catalysis.
- Their tunable nature and broad metal coordination enhance their utility.
- Continued development promises further applications in organic synthesis.
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