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Anticancer Perspectives on the Fungal-Derived Polyphenolic Hispolon
Muhammad T Islam1,2, Eunus S Ali3,4, Ishaq N Khan5
1Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam
Background:
Cancer is a dreadful disease causing thousands of deaths per year worldwide, which requires precision diagnostics and therapy. Although the selection of therapeutic regimens depends on the cancer type, chemotherapy remains a sustainable treatment strategy despite some of its known side-effects. To date, a number of natural products and their derivatives or analogues have been investigated as potent anticancer drugs. These drug discoveries have aimed for targeted therapy and reduced side-effects, including natural therapeutic regimens.
Objective:
This review introduces a prospective fungal-derived polyphenol, Hispolon (HIS), as an anticancer agent. Accordingly, this review focuses on exploring the anticancer effect of hispolon based on information extracted from databases such as PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar.
Methods:
A literature search in PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar was accomplished, using the keyword 'Hispolon', pairing with 'cancer', 'cytotoxicity', 'cell cycle arrest', 'apoptosis', 'metastasis', 'migration', 'invasion', 'proliferation', 'genotoxicity', 'mutagenicity', 'drug-resistant cancer', 'autophagy', and 'estrogen receptor.
Results:
Database-dependent findings from reported research works suggest that HIS can exert anticancer effects by modulating multiple molecular and biochemical pathways, including cell cycle arrest, apoptosis, autophagy, inhibition of proliferation, metastasis, migration, and invasion. Moreover, HIS inhibits the estrogenic activity and exhibits chemoprevention prospects, possibly due to its protective effects such as anticancer and anti-inflammatory mechanisms. To date, a number of HIS derivatives and analogues have been introduced for their anticancer effects in numerous cancer cell lines.
Conclusion:
Data obtained from this review suggest that hispolon and some of its derivatives can be promising anticancer agents, and may become plant-based cancer chemotherapeutic leads for the development of potent anticancer drugs, alone or in combination with other chemotherapeutic agents.
Insights
Hispolon, a fungal polyphenol, shows significant anticancer potential by targeting multiple pathways. This natural compound and its derivatives may lead to new plant-based chemotherapy drugs for cancer treatment.
Area of Science:
- Natural Product Chemistry
- Pharmacology
- Oncology
Background:
- Chemotherapy is a vital cancer treatment, but side effects necessitate novel therapeutic strategies.
- Natural products and their derivatives are being explored for targeted cancer therapy with reduced toxicity.
- Hispolon (HIS), a fungal-derived polyphenol, is emerging as a promising anticancer agent.
Purpose of the Study:
- To review the anticancer effects of Hispolon (HIS).
- To explore HIS's potential as a lead compound for developing new anticancer drugs.
Main Methods:
- Comprehensive literature search using PubMed, ScienceDirect, MedLine, Web of Science, and Google Scholar.
- Keywords included 'Hispolon' combined with terms related to cancer, cytotoxicity, cell cycle, apoptosis, metastasis, migration, invasion, proliferation, genotoxicity, drug resistance, autophagy, and estrogen receptor.
Main Results:
- Hispolon demonstrates anticancer activity by modulating key molecular pathways, including cell cycle arrest, apoptosis, and autophagy.
- HIS inhibits cancer cell proliferation, metastasis, migration, and invasion.
- Hispolon exhibits chemopreventive properties and inhibits estrogenic activity, with potential anti-inflammatory effects.
Conclusions:
- Hispolon and its derivatives show promise as anticancer agents.
- These natural compounds could serve as leads for developing novel plant-based chemotherapeutic drugs.
- HIS may be used alone or in combination with existing chemotherapy agents.
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