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Regioselective Sulfonylvinylation of the Unactivated C(sp3)-H Bond via a C-Centered Radical-Mediated Hydrogen Atom
Shan Yang1, Xinxin Wu1, Shuo Wu1
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , 199 Ren-Ai Road , Suzhou , Jiangsu 215123 , People's Republic of China.
Abstract:
Given the similarity of multiple sp3 C-H bonds in electronic properties and bond dissociation energy (BDE), regioselective sp3 C-H bond functionalization remains a paramount challenge. Here, we report a C-centered radical-mediated approach for site-specific sulfonylvinylation of the C(sp3)-H bond via the hydrogen atom transfer (HAT) process. The reaction features mild conditions, broad substrate scope, and high regioselectivity and stereoselectivity, manifesting the nontrivial synthetic potential.
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