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Updated: Jan 23, 2026

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
Published on: October 26, 2018
Bioconjugated arylpalladium complexes on solid supports for a convenient last-step synthesis of 11C-labelled tracers
Alexis Tabey1, Hélène Audrain2, Eric Fouquet1
1Univ. Bordeaux, CNRS, Bordeaux INP, ISM, UMR 5255, F-33400, Talence, France. eric.fouquet@u-bordeaux.fr philippe.hermange@u-bordeaux.fr.
Abstract:
Arylpalladium complexes prepared from o-iodobenzylalcohol-biomolecule conjugates and triphenylphosphine linked on polystyrene beads provided convenient supported and stable precursors. These heterogeneous substrates could react smoothly with [11C]CO, affording the corresponding 11C-labelled bioconjugates with isolated radiochemical yields ranging from 4% to 71%, and excellent radiochemical purities from 86% to >98% after a simple filtration. Thus, this method opens up a new pathway for an easier automation of Pd-catalysed syntheses of PET tracers.
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