Related Experiment Video
Updated: Jan 23, 2026

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture
Published on: January 11, 2016
A Modular Construction of Epidithiodiketopiperazines
Thomas N Snaddon1, Toya D Scaggs1, Colin M Pearson1
1Department of Chemistry , Indiana University , 800 East Kirkwood Avenue , Bloomington , Indiana 47405 , United States.
Abstract:
Epidithiodiketopiperazines (ETPs) possess remarkably diverse biological activities and have attracted significant synthetic attention. The preparation of analogues is actively pursued; however, they are structurally challenging, and more direct and modular methods for their synthesis are desirable. To this end, the utility of a bifunctional triketopiperazine building block for the straightforward synthesis of ETPs is reported. A modular strategy consisting of enolate alkylation followed by site-selective nucleophile addition enables the concise synthesis of (±)-hyalodendrin and a range of analogues.
Related Concept Videos
Bode Plots Construction
Construction of Root Locus
For positive gain values, the root locus exists on the real axis to the left of an odd number of finite open-loop poles or zeros. The root locus starts at the open-loop poles and traces the paths of the closed-loop poles as the gain...
Construction of Frequency Distribution
First, make a table with two columns—one with the title of the data that needs to be organized, and the other column for frequency. [Draw a third column for tally marks if needed]. Then, take a look at the items given in the data set and decide if an ungrouped frequency distribution table or a grouped frequency distribution table would be more suitable. If there are large sets of different values, then it is...
Design Example: Dimensioning of Concrete Masonry Construction
The site engineer has laid out a plan for the storeroom with external dimensions of twelve feet in length and...
RNA Polymerase II Accessory Proteins
X-ray Crystallography
Diffraction
Diffraction is the change in the direction of travel experienced by an electromagnetic wave when it encounters a physical barrier whose dimensions are comparable to those of the wavelength of the light. X-rays are electromagnetic radiation with wavelengths about as long as the distance between neighboring...

